NanoSafety Cluster Week
EU NanoSafety Cluster Week "Building confidence in risk assessment and governance of Nanomaterials Innovation".
The 4-day event kicks off with the caLIBRAte final workshop focused on current knowledge and future outlook on stakeholder risk perception and information needs and nanosafety data availability. caLIBRAte also presents nano-specific human and environmental risk assessment and management tools tested in the project, plus the decision support tool developed, the NanoRisk Governance Portal.
A two-day Nanosafety Cluster Scientific Conference then follows, organised and sponsored by the projects NanoCommons, NanoSolveIT and NanoInformaTIX, focused on the increasingly important roles of data accessibility and predictive modelling in nanomaterials governance and risk assessment.
Towards in silico nanosafety assessment – integrating experimental and computational approaches includes oral and poster presentations from Nanosafety Cluster projects to update the community on latest nanosafety research and set the direction for the next 4 years via the nanoinformatics and nanosafety governance projects.
NanoSafety Cluster business closes the week, including an open NSC meeting to which all are welcome to contribute, Working Group meetings to progress key community-driven activities, and a Steering Group meeting. In parallel, a training session on the caLIBRAte Nano Risk Governance Portal and underlying risk assessment, management and decision support tools will be offered.
Resources & Training materials
The aim is to introduce unique approach of the ACEnano Knowledge Protocols and Data
warehouse designed to disseminate protocols and their variations and to store, manage and
share data for physico-chemical characterisation of nanomaterials under standard conditions
as well as at different life stages.
ACEnano knowledge infrastructure (KI) supports the activities related to data collection and method optimisation in the area of physicochemical characterisation of nanomaterials. The KI provides a central place to access harmonised and standardised methods and data, supporting the implementation of Findable, Accessible, Interoperable and Reusable (FAIR) data principles, the reproducibility and documentation process towards the goal of generating reference resources for nanomaterials risk assessment.
The KI includes instances to accommodate data and protocols. The protocols database facilitates adding, sharing and comparing methods in a questionnaire-like format guiding users through the documentation process from starting material identification to sample preparation, measurement and data processing. The data warehouse offers long-term storage of the results in a reusable format that are directly linked to the methods applied.
A public version of the data warehouse is being integrated in the NanoCommons ecosystem. By semantic annotation and linking, this guarantees harmonisation and interoperability with other data sources of the EU NanoSafety Cluster like the eNanoMapper and NanoFASE.
The development of the KI is supported by ACEnano (EU Horizon 2020 NMBP project no. 720952), while its availability to a wider community is assured by the activities in NanoCommons (Horizon 2020 INFRAIA project no. 731032).
NanoCommons (Horizon 2020 INFRAIA, project no. 731032) aims to provide a standardised, reproducible and interoperable way to access available data, knowledge, analysis and modelling tools that have been adapted and verified as suitable for application to nanomaterials.
One of the major goals is to reduce the fragmentation of nanosafety related data and knowledge by aligning and semantically linking available resources major European and international nanosafety projects and infrastructures, providing new harmonized resources when needed and ensuring access following the FAIR principles (Findable, Accessible, Interoperable and Re-usable) whenever possible in an open and free manner. Outputs to be shared via the NanoCommons knowledge infrastructure include: i) Central data access to stored data or linked data sources via a variety of mechanisms (e.g. web interfaces, application programming interfaces), ii) Metadata-rich datasets from experiments and modelling/simulations, iii) Protocols and Standard Operating Procedures, iv) Quality Assurance, v) Concepts, guidance and templates for data curation, vi) Automated annotation pipelines, and vii) Data standards. This integrated design offers easy and harmonized access to a variety of datasets (physicochemical, hazard, exposure, fate) as well as data management, data mining and data visualisation tools to researchers from academia and industry, as well as regulators, ensuring their optimal use and joint development.
NanoCommons – Assistance with Data Management & Nanoinformatics Tools
Bringing nano-enabled developments to the market still faces challenges along up-scaling processes and safety evaluation  and needs to be addressed in a structured way . In addition, a major aim is to assess the safety profiles of engineered nanomaterials (ENMs) at low, nonlethal dosages and extended repetitive exposures, which could help to understand long-term consequences of ENMs’ interactions with biological environments and further expedite their translation into products and applications.
To enable this translation, data plays a prominent role. And here is where NanoCommons, the e-infrastructure project, as one of the three EU-H2020 data relevant projects (together with NanoSolveIT and NanoinformaTIX) can help nanosafety researchers from industry, academia and regulatory bodies to access the state-of-the-art data management expertise. Thus, users/collaborators can take advantage of the NanoCommons services, facilities and knowledge to advance their work, solve problems and take their research to the next level.
Within this contribution, it is presented, how NanoCommons, by means of its transnational actions (TAs), brings benefits to its users/collaborators: (i) EU funded access to expertise in data management and nanoinformatics tools; (ii) Facilitate open access data to help reduce duplication of tests, regulation, animal-testing, bureaucracy…; (iii) Assistance with capture and databasing of data to comply with EU open data initiatives and achieve FAIR data principles; (iv) model development; and many more.
 Falk, A., Schimpel, C., Haase, A., Hazebrouck, B., Fito López, C., Prina-Mello, A., Savolainen, K., Sips, A., Lopez de Ipiña, J., Lynch, I., Charitidis, C., Visser, G. (2016). “Closer to the market”-Roadmap (CTTM). Zenodo. DOI: https://zenodo.org/record/1493492
 Schimpel, C., Resch, S., Flament, G., Carlander, D., Vaquero, C., Bustero, I., Falk, A. (2018). A methodology on how to create a real-life relevant risk profile for a given nanomaterial. Journal of Chemical Health and Safety, 25(1), 12-23.
 NanoCommons: https://www.nanocommons.eu/